Spontaneous parkinsonisms and striatal impairment in neuroleptic free youth at ultrahigh risk for psychosis.

ABSTRACT: Spontaneous movement abnormalities, occurring independent of medication status, are thought to reflect basal ganglia pathology in patients at ultrahigh risk (UHR) for psychosis. To date, the research literature has primarily focused on movements associated with elevated striatal dopamine (i.e., hyperkinesia) while little is known about motor symptoms associated with low levels of subcortical dopamine (i.e., spontaneous parkinsonisms; SPs). As SPs (e.g., bradykinesia) may be governed by distinct neural mechanisms, this line of research can provide a clearer picture of the etiological processes in the prodrome. AIMS: To examine SPs and striatal structural correlates in youth at risk for psychosis. A total of 81 (35 UHR, 46 healthy controls) adolescents were administered a structured clinical

SUBMITTER: Dean DJ 

PROVIDER: S-EPMC4657751 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature