Ontology highlight
ABSTRACT:
SUBMITTER: Hricik DE
PROVIDER: S-EPMC4657844 | biostudies-literature | 2015 Dec
REPOSITORIES: biostudies-literature
Hricik Donald E DE Formica Richard N RN Nickerson Peter P Rush David D Fairchild Robert L RL Poggio Emilio D ED Gibson Ian W IW Wiebe Chris C Tinckam Kathryn K Bunnapradist Suphamai S Samaniego-Picota Milagros M Brennan Daniel C DC Schröppel Bernd B Gaber Osama O Armstrong Brian B Ikle David D Diop Helena H Bridges Nancy D ND Heeger Peter S PS
Journal of the American Society of Nephrology : JASN 20150429 12
Concerns about adverse effects of calcineurin inhibitors (CNIs) have prompted development of protocols that minimize their use. Whereas previous CNI withdrawal trials in heterogeneous cohorts showed unacceptable rates of acute rejection (AR), we hypothesized that we could identify individuals capable of tolerating CNI withdrawal by targeting immunologically quiescent kidney transplant recipients. The Clinical Trials in Organ Transplantation-09 Trial was a randomized, prospective study of nonsens ...[more]