A Randomized Trial of Time-Limited Antiretroviral Therapy in Acute/Early HIV Infection.

ABSTRACT:

Background

It has been proposed that initiation of antiretroviral treatment (ART) very soon after establishment of HIV infection may be beneficial by improving host control of HIV replication and delaying disease progression.

Methods

People with documented HIV infection of less than 12 months' duration in Baltimore MD and seven Canadian sites were randomized to either a) observation and deferred ART, or b) immediate treatment with ART for 12 months. All subjects not receiving ART were followed quarterly and permanent ART was initiated according to contemporaneous treatment guidelines. The endpoint of the trial was total ART-free time from study entry until initiation of permanent ART.

Results

One hundred thirteen people were randomized, 56 to the observation arm and 5

SUBMITTER: Margolick JB 

PROVIDER: S-EPMC4658016 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature