Investigation of Yersinia pestis Laboratory Adaptation through a Combined Genomics and Proteomics Approach.

ABSTRACT: The bacterial pathogen Yersinia pestis, the cause of plague in humans and animals, normally has a sylvatic lifestyle, cycling between fleas and mammals. In contrast, laboratory-grown Y. pestis experiences a more constant environment and conditions that it would not normally encounter. The transition from the natural environment to the laboratory results in a vastly different set of selective pressures, and represents what could be considered domestication. Understanding the kinds of adaptations Y. pestis undergoes as it becomes domesticated will contribute to understanding the basic biology of this important pathogen. In this study, we performed a parallel serial passage experiment (PSPE) to explore the mechanisms by which Y. pestis adapts to laboratory conditions, hypothesizing that cells

SUBMITTER: Leiser OP 

PROVIDER: S-EPMC4658026 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature