The Roles of Dopamine and Hypocretin in Reward: A Electroencephalographic Study.

ABSTRACT: The proper functioning of the mesolimbic reward system is largely dependent on the neurotransmitter dopamine. Recent evidence suggests that the hypocretin system has significant projections to this reward system. We examined the distinct effects of reduced dopamine or reduced hypocretin levels on reward activity in patients with Parkinson's disease, dopamine deficient, as well as patients with narcolepsy-cataplexy, hypocretin depleted, and healthy controls. Participants performed a simple game-like task while high-density electroencephalography was recorded. Topography and timing of event-related potentials for both reward cue, and reward feedback was examined across the entire dataset. While response to reward cue was similar in all groups, two distinct time points were found to distingui

SUBMITTER: Mensen A 

PROVIDER: S-EPMC4658140 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature