Association of Baseline Characteristics and Early Vision Response with 2-Year Vision Outcomes in the Comparison of AMD Treatments Trials (CATT).

ABSTRACT:

Purpose

To evaluate the association of baseline characteristics and early visual acuity (VA) response with visual outcomes at years 1 or 2 in the Comparison of Age-Related Macular Degeneration (AMD) Treatments Trials (CATT).

Design

Secondary analysis of CATT.

Participants

The 1185 CATT participants with baseline VA of 20/25 to 20/320.

Methods

Participants were assigned to ranibizumab or bevacizumab and to 1 of 3 dosing regimens. Associations of baseline characteristics and early VA response (week 4 or 12) with VA response at years 1 or 2 were assessed by R(2) from linear regression analyses. Patients who had a poor initial response (VA 20/40 or worse with persistent fluid and without ≥1-line VA gain) were defined as candidates for changing treatment.

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SUBMITTER: Ying GS 

PROVIDER: S-EPMC4658285 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature