Complex genetics of pulmonary diseases: lessons from genome-wide association studies and next-generation sequencing.

ABSTRACT: The advent of high-throughput technologies has provided exceptional assistance for lung scientists to discover novel genetic variants underlying the development and progression of complex lung diseases. However, the discovered variants thus far do not explain much of the estimated heritability of complex lung diseases. Here, we review the literature of successfully used genome-wide association studies (GWASs) and identified the polymorphisms that reproducibly underpin the susceptibility to various noncancerous complex lung diseases or affect therapeutic responses. We also discuss the inherent limitations of GWAS approaches and how the use of next-generation sequencing technologies has furthered our understanding about the genetic determinants of these diseases. Next, we describe the contri

SUBMITTER: Pouladi N 

PROVIDER: S-EPMC4658294 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature