Clinicopathological study on TTV infection in hepatitis of unknown etiology.

ABSTRACT:

Aim

To investigate the state of infection, replication site, pathogenicity and clinical significance of transfusion transmitted virus (TTV) in patients with hepatitis, especially in patients of unknown etiology.

Methods

Liver tissues taken from 136 cases of non-A non-G hepatitis were tested for TT virus antigen and nucleic acid by in situ hybridization (ISH) and nested-polymerase chain reaction (PCR). Among them, TT virus genome and its complemental strand were also detected in 24 cases of autopsy liver and extrahepatic tissues with ISH. Meanwhile, TTV DNA was detected in the sera of 187 hepatitis patients by nested-PCR. The pathological and clinical data of the cases infected with TTV only were analyzed.

Results

In liver, the total positive rate of TTV DNA was 32.4%

SUBMITTER: Hu ZJ 

PROVIDER: S-EPMC4658368 | biostudies-literature | 2002 Apr

REPOSITORIES: biostudies-literature