Xenobiotic Metabolism in Mice Lacking the UDP-Glucuronosyltransferase 2 Family.

ABSTRACT: UDP-Glucuronosyltransferases (UGTs) conjugate a glucuronyl group from glucuronic acid to a wide range of lipophilic substrates to form a hydrophilic glucuronide conjugate. The glucuronide generally has decreased bioactivity and increased water solubility to facilitate excretion. Glucuronidation represents an important detoxification pathway for both endogenous waste products and xenobiotics, including drugs and harmful industrial chemicals. Two clinically significant families of UGT enzymes are present in mammals: UGT1s and UGT2s. Although the two families are distinct in gene structure, studies using recombinant enzymes have shown considerable overlap in their ability to glucuronidate many substrates, often obscuring the relative importance of the two families in the clearance of particul

SUBMITTER: Fay MJ 

PROVIDER: S-EPMC4658492 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature