The National Lung Matrix Trial: translating the biology of stratification in advanced non-small-cell lung cancer.

ABSTRACT:

Background

The management of NSCLC has been transformed by stratified medicine. The National Lung Matrix Trial (NLMT) is a UK-wide study exploring the activity of rationally selected biomarker/targeted therapy combinations.

Patients and methods

The Cancer Research UK (CRUK) Stratified Medicine Programme 2 is undertaking the large volume national molecular pre-screening which integrates with the NLMT. At study initiation, there are eight drugs being used to target 18 molecular cohorts. The aim is to determine whether there is sufficient signal of activity in any drug-biomarker combination to warrant further investigation. A Bayesian adaptive design that gives a more realistic approach to decision making and flexibility to make conclusions without fixing the sample size was ch

SUBMITTER: Middleton G 

PROVIDER: S-EPMC4658545 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature