Association between the MYO9B polymorphisms and celiac disease risk: a meta-analysis.

ABSTRACT:

Background

There is no consensus regarding the association between polymorphisms in the myosin IXB (MYO9B) gene and celiac disease (CD) risk. In this study, we performed a meta-analysis to evaluate genetic variants in MYO9B with CD.

Methods

Four MYO9B polymorphisms (rs1545620, rs1457092, rs2305767 and rs2305764) were assessed. A literature search was conducted using PubMed, Scopus, and Web of Science databases until June 2015. Odds ratio (OR) and 95% confidence interval (CI) were used to investigate the strength of the association under dominant, recessive, homozygote and allelic comparison models.

Results

Seven case-control studies with a total of 1965 CD patients and 4894 controls were included in this meta-analysis. The results showed that rs1545620 was associated

SUBMITTER: Liao N 

PROVIDER: S-EPMC4658862 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature