Prospective cohort study to evaluate the efficacy of taxane plus platinum and CPT-11plus platinum regimes and to identify prognostic risk factors in cervical cancer patients.

ABSTRACT:

Objective

This study was designed to evaluate the response, toxicity and survival of taxanes plus platinum (TP) and CPT-11plus platinum (CP) as neoadjuvant chemotherapies with previously untreated cervical cancer, and to identify prognostic risk factors in these patients.

Methods

A cohort study was performed to evaluate the result of TP and CP regimes in the treatment of cervical cancer patients.

Results

The study included 567 patients with locally advanced cervical cancer (LACC) staged as FIGO IB-IIB in our clinical departments. Clinical response was found in 76.1% and 78% of patients in the TP and CP arms, respectively, and no treatment-related deaths were reported. During the follow-up period, disease-free survival (DFS) and overall survival (OS) for the TP and CP

SUBMITTER: Huang K 

PROVIDER: S-EPMC4658875 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature