CD36 genotype associated with ischemic stroke in Chinese Han.

ABSTRACT:

Objective

CD36 is involved in oxidant stress, hyperlipidemia, and thrombosis in the pathology of stroke. CD 36 single nucleotide polymorphisms (SNPs) were reported to be associated with abnormalities of serum FA, triglyceride level and to increase risk of metabolic syndrome, coronary artery disease and type 2 diabetes. Based on these finding we hypothesized that CD36 is an important candidate gene of stroke; therefore, we set out a case-control study to explore the association of CD36 SNPs with ischemic stroke.

Methods

We enrolled 374 patients with atherothrombotic stroke as cases and 1,013 people without stroke as controls. CD36 rs3211842, rs3211870, rs1761667, rs9784998, and rs10499859 loci were detected by PCR-ligase detection reaction.

Results

Only rs1761667 (P=0.

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC4659017 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature