Clinical role of circulating miR-223 as a novel biomarker in early diagnosis of cancer patients.

ABSTRACT:

Background

Current diagnostic procedures of cancers are invasive and non-specific. MicroRNAs (miRNAs) have become promising molecular markers for gastric cancer (GC) predication. However, there have been inconsistencies in the literature regarding the suitability of circulating miRNAs for early detection of cancers.

Methods

We performed a comprehensive meta-analysis to integrate an evaluation index for diagnostic accuracy of miR-223 in diagnosing cancer patients. Furthermore, we conducted an independent validation set of 50 gastric cancer patients and 50 healthy controls comparing miR-223 expression. We also analyzed miR-223 expression in vitro.

Results

A total of 11 studies met the inclusion criteria and therefore included in this meta-analysis. We found that miR-223

SUBMITTER: Zhou X 

PROVIDER: S-EPMC4659128 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature