Production of phenylacetyl-homoserine lactone analogs by artificial biosynthetic pathway in Escherichia coli.

ABSTRACT:

Background

Quorum sensing (QS) networks are more commonly known as acyl homoserine lactone (HSL) networks. Recently, p-coumaroyl-HSL has been found in a photosynthetic bacterium. p-coumaroyl-HSL is derived from a lignin monomer, p-coumaric acid, rather than a fatty acyl group. The p-coumaroyl-HSL may serve an ecological role in diverse QS pathways between p-coumaroyl-HSL producing bacteria and specific plants. Interference with QS has been regarded as a novel way to control bacterial infections. Heterologous production of the QS molecule, p-coumaroyl-HSL, could provide a sustainable and controlled means for its large-scale production, in contrast to the restricted feedback regulation and extremely low productivity of natural producers.

Results

We developed an artificial bios

SUBMITTER: Kang SY 

PROVIDER: S-EPMC4659178 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature