Regulatory network reconstruction reveals genes with prognostic value for chronic lymphocytic leukemia.

ABSTRACT:

Background

The clinical course of chronic lymphocytic leukemia (CLL) is highly variable; some patients follow an indolent course, but others progress to a more advanced stage. The mutational status of rearranged immunoglobulin heavy chain variable (IGVH) genes in CLL is a feature that is widely recognized for dividing patients into groups that are related to their prognoses. However, the regulatory programs associated with the IGVH statuses are poorly understood, and markers that can precisely predict survival outcomes have yet to be identified.

Methods

In this study, (i) we reconstructed gene regulatory networks in CLL by applying an information-theoretic approach to the expression profiles of 5 cohorts. (ii) We applied master regulator analysis (MRA) to these networks to i

SUBMITTER: Yepes S 

PROVIDER: S-EPMC4659237 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature