Changes in microbiota during experimental human Rhinovirus infection.

ABSTRACT:

Background

Human Rhinovirus (HRV) is responsible for the majority of common colds and is frequently accompanied by secondary bacterial infections through poorly understood mechanisms. We investigated the effects of experimental human HRV serotype 16 infection on the upper respiratory tract microbiota.

Methods

Six healthy volunteers were infected with HRV16. We performed 16S ribosomal RNA-targeted pyrosequencing on throat swabs taken prior, during and after infection. We compared overall community diversity, phylogenetic structure of the ecosystem and relative abundances of the different bacteria between time points.

Results

During acute infection strong trends towards increases in the relative abundances of Haemophilus parainfluenzae and Neisseria subflava were observ

SUBMITTER: Hofstra JJ 

PROVIDER: S-EPMC4659412 | biostudies-literature | 2015 Aug

REPOSITORIES: biostudies-literature