A new Otogelin ENU mouse model for autosomal-recessive nonsyndromic moderate hearing impairment.

ABSTRACT: Approximately 10 % of the population worldwide suffers from hearing loss (HL) and about 60 % of persons with early onset HL have hereditary hearing loss due to genetic mutations. Highly efficient mutagenesis in mice with the chemical mutagen, ethylnitrosourea (ENU), associated with relevant phenotypic tools represents a powerful approach in producing mouse models for hearing impairment. A benefit of this strategy is to generate alleles to form a series revealing the full spectrum of gene function in vivo. It can also mimic the range of human mutations and polymorphisms for HL. In the course of a genome ENU mutagenesis program, we selected a new mouse model for hearing defect based on a dysmorphological screen. We identified by gene mapping the mutation responsible for this phenotype and ch

SUBMITTER: El Hakam Kamareddin C 

PROVIDER: S-EPMC4659790 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature