Scene unseen: Disrupted neuronal adaptation in melancholia during emotional film viewing.

ABSTRACT: Impairments in attention and concentration are distinctive features of melancholic depression, and may diminish the ability to shift focus away from internal dysphoric states. Disrupted brain networks may underlie the inability to effectively disengage from interoceptive signals in this disorder. This study investigates changes in effective connectivity between cortical systems supporting attention, interoception, and perception in those with melancholic depression when shifting attention from rest to viewing dynamic film stimuli. We hypothesised that those with melancholia would show impaired attentional shifting from rest to emotional film viewing, captured in neuronal states that differed little across conditions. Functional magnetic resonance imaging (fMRI) data were acquired from 48 p

SUBMITTER: Hyett MP 

PROVIDER: S-EPMC4660155 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature