Postnatal Infections and Immunology Affecting Chronic Lung Disease of Prematurity.

ABSTRACT: Premature infants suffer significant respiratory morbidity during infancy with long-term negative consequences on health, quality of life, and health care costs. Enhanced susceptibility to a variety of infections and inflammation play a large role in early and prolonged lung disease following premature birth, although the mechanisms of susceptibility and immune dysregulation are active areas of research. This article reviews aspects of host-pathogen interactions and immune responses that are altered by preterm birth and that impact chronic respiratory morbidity in these children.

SUBMITTER: Pryhuber GS 

PROVIDER: S-EPMC4660246 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature