Depression and Suicidality Outcomes in the Treatment of Early Age Mania Study.

ABSTRACT:

Objective

To assess the efficacy of mood-stabilizing medications for depression and suicidality in pediatric bipolar disorder.

Method

The Treatment of Early Age Mania (TEAM) study is a multicenter, prospective, randomized, masked comparison of divalproex sodium (VAL), lithium carbonate (LI), and risperidone (RISP) in an 8-week parallel clinical trial. A total of 279 children and adolescents with DSM-IV diagnoses of bipolar I disorder, mixed or manic, aged 6 to 15 years were enrolled. The primary outcome measure was improvement on the Clinical Global Impression scale for depression (CGI-BP-I-D). Secondary outcome measures included the Children's Depression Rating Scale (CDRS-R) and suicidality status. Statistics included longitudinal analysis of outcomes using generalized lin

SUBMITTER: Salpekar JA 

PROVIDER: S-EPMC4660262 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature