Magnetite-Amyloid-β deteriorates activity and functional organization in an in vitro model for Alzheimer's disease.

ABSTRACT: The understanding of the key mechanisms behind human brain deterioration in Alzheimer' disease (AD) is a highly active field of research. The most widespread hypothesis considers a cascade of events initiated by amyloid-β peptide fibrils that ultimately lead to the formation of the lethal amyloid plaques. Recent studies have shown that other agents, in particular magnetite, can also play a pivotal role. To shed light on the action of magnetite and amyloid-β in the deterioration of neuronal circuits, we investigated their capacity to alter spontaneous activity patterns in cultured neuronal networks. Using a versatile experimental platform that allows the parallel monitoring of several cultures, the activity in controls was compared with the one in cultures dosed with magnetite, amyloid-β an

SUBMITTER: Teller S 

PROVIDER: S-EPMC4660300 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature