Fitting Proportional Odds Model to Case-Control data with Incorporating Hardy-Weinberg Equilibrium.

ABSTRACT: Genetic association studies have been proved to be an efficient tool to reveal the aetiology of many human complex diseases and traits. When the phenotype is binary, the logistic regression model is commonly employed to evaluate the association strength of the genetic variants predispose to human diseases because the maximum likelihood estimator of the odds ratio based on case-control data is equivalent to that from the same model by taking the data as being arisen prospectively. This equivalence does not hold for the proportional odds model and using it to analyze the case-control data directly often results in a substantial bias. Through putting a parameter of the minor allele frequency in the modified likelihood function under the condition that the Hardy-Weinberg equilibrium law holds

SUBMITTER: Zhang W 

PROVIDER: S-EPMC4660314 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature