The P2X7 receptor regulates cell survival, migration and invasion of pancreatic ductal adenocarcinoma cells.

ABSTRACT:

Background

Pancreatic ductal adenocarcinoma (PDAC) is presently one of the cancers with the worst survival rates and least effective treatments. Moreover, total deaths due to PDAC are predicted to increase in the next 15 years. Therefore, novel insights into basic mechanism of PDAC development and therapies are needed. PDAC is characterized by a complex microenvironment, in which cancer and stromal cells release different molecules, such as ATP. ATP can be transported and/or exocytosed from active cancer cells and released from dying cells in the necrotic core of the cancer. We hypothesized that one of the ATP receptors, the P2X7 receptor (P2X7R) could be an important player in PDAC behaviour.

Methods

We determined the expression (real time PCR and Western blot) and localiza

SUBMITTER: Giannuzzo A 

PROVIDER: S-EPMC4660609 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature