Improvement of prognostic performance in severely injured patients by integrated clinico-transcriptomics: a translational approach.

ABSTRACT:

Introduction

Severe trauma triggers a systemic inflammatory response that contributes to secondary complications, such as nosocomial infections, sepsis or multi-organ failure. The present study was aimed to identify markers predicting complications and an adverse outcome of severely injured patients by an integrated clinico-transcriptomic approach.

Methods

In a prospective study, RNA samples from circulating leukocytes from severely injured patients (injury severity score ≥ 17 points; n = 104) admitted to a Level I Trauma Center were analyzed for dynamic changes in gene expression over a period of 21 days by quantitative RT-PCR. Transcriptomic candidates were selected based on whole genome screening of a representative discovery set (n = 10 patients) or known mechanisms of t

SUBMITTER: Rittirsch D 

PROVIDER: S-EPMC4660831 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature