Multi-platform microRNA profiling of hepatoblastoma patients using formalin fixed paraffin embedded archival samples.

ABSTRACT:

Background

Formalin fixed paraffin embedded (FFPE) samples are a valuable resource in cancer research and have the potential to be extensively used. However, they are often underused because of degradation and chemical modifications occurring in the RNA that can present obstacles in downstream analysis. In routine medical care, FFPE material is examined and archived, therefore clinical collections of many types of cancers exist. It is beneficial to assess and record the quality of data that can be obtained from this type of material. The current study investigated three independent platforms and their ability to profile microRNAs (miRNAs) within FFPE samples from hepatoblastoma (HB) patients.

Findings

Here we present three types of datasets consisting of miRNA profiles for 1

SUBMITTER: Leichter AL 

PROVIDER: S-EPMC4660849 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature