Assessment of osteoarthritis candidate genes in a meta-analysis of nine genome-wide association studies.

ABSTRACT:

Objective

To assess candidate genes for association with osteoarthritis (OA) and identify promising genetic factors and, secondarily, to assess the candidate gene approach in OA.

Methods

A total of 199 candidate genes for association with OA were identified using Human Genome Epidemiology (HuGE) Navigator. All of their single-nucleotide polymorphisms (SNPs) with an allele frequency of >5% were assessed by fixed-effects meta-analysis of 9 genome-wide association studies (GWAS) that included 5,636 patients with knee OA and 16,972 control subjects and 4,349 patients with hip OA and 17,836 control subjects of European ancestry. An additional 5,921 individuals were genotyped for significantly associated SNPs in the meta-analysis. After correction for the number of independent tes

SUBMITTER: Rodriguez-Fontenla C 

PROVIDER: S-EPMC4660891 | biostudies-literature | 2014 Apr

REPOSITORIES: biostudies-literature