Coupling of α,α-difluoro-substituted organozinc reagents with 1-bromoalkynes.

ABSTRACT: α,α-Difluoro-substituted organozinc reagents generated from conventional organozinc compounds and difluorocarbene couple with 1-bromoalkynes affording gem-difluorinated alkynes. The cross-coupling proceeds in the presence of catalytic amounts of copper iodide in dimethylformamide under ligand-free conditions.

SUBMITTER: Zemtsov AA 

PROVIDER: S-EPMC4660974 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature