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Coupling of α,α-difluoro-substituted organozinc reagents with 1-bromoalkynes.

ABSTRACT: α,α-Difluoro-substituted organozinc reagents generated from conventional organozinc compounds and difluorocarbene couple with 1-bromoalkynes affording gem-difluorinated alkynes. The cross-coupling proceeds in the presence of catalytic amounts of copper iodide in dimethylformamide under ligand-free conditions.

SUBMITTER: Zemtsov AA 

PROVIDER: S-EPMC4660974 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature

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Coupling of α,α-difluoro-substituted organozinc reagents with 1-bromoalkynes.

Zemtsov Artem A AA   Volodin Alexander D AD   Levin Vitalij V VV   Struchkova Marina I MI   Dilman Alexander D AD  

Beilstein journal of organic chemistry 20151110

α,α-Difluoro-substituted organozinc reagents generated from conventional organozinc compounds and difluorocarbene couple with 1-bromoalkynes affording gem-difluorinated alkynes. The cross-coupling proceeds in the presence of catalytic amounts of copper iodide in dimethylformamide under ligand-free conditions. ...[more]

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