SBRT and extreme hypofractionation: A new era in prostate cancer treatments?

ABSTRACT:

Aim

Radiation therapy (RT) is a standard therapeutic option for prostate cancer (PC). In the last decades, several innovative technology applications have been introduced. 3-Dimensional conformal RT, volumetric/rotational intensity modulated RT associated or not with image-guided RT, are becoming largely diffused in the treatment of PC.

Background

Considering that PC could have a low α/β ratio, similar to late-reacting normal tissues, it could also be highly responsive to fraction size. Thus, the reduction of the number of fractions and the increase of the dose/fraction seem to be reasonable choices in the treatment of this cancer. This review reported the technology evolution, the radiobiological and the clinical data about the role of extreme hypofractionated RT in the tre

SUBMITTER: Alongi F 

PROVIDER: S-EPMC4661355 | biostudies-literature | 2015 Nov-Dec

REPOSITORIES: biostudies-literature