The Solution Structure of the Lantibiotic Immunity Protein NisI and Its Interactions with Nisin.

ABSTRACT: Many Gram-positive bacteria produce lantibiotics, genetically encoded and posttranslationally modified peptide antibiotics, which inhibit the growth of other Gram-positive bacteria. To protect themselves against their own lantibiotics these bacteria express a variety of immunity proteins including the LanI lipoproteins. The structural and mechanistic basis for LanI-mediated lantibiotic immunity is not yet understood. Lactococcus lactis produces the lantibiotic nisin, which is widely used as a food preservative. Its LanI protein NisI provides immunity against nisin but not against structurally very similar lantibiotics from other species such as subtilin from Bacillus subtilis. To understand the structural basis for LanI-mediated immunity and their specificity we investigated the structure

SUBMITTER: Hacker C 

PROVIDER: S-EPMC4661402 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature