Viral meningitis epidemics and a single, recent, recombinant and anthroponotic origin of swine vesicular disease virus.

ABSTRACT:

Background and objectives

Swine vesicular disease virus (SVDV) is a close relative of the human Enterovirus B serotype, coxsackievirus B5. As the etiological agent of a significant emergent veterinary disease, several studies have attempted to explain its origin. However, several key questions remain, including the full biological ancestry of the virus, and its geographical and temporal origin.

Methodology

We sequenced near-complete genomes of 27 SVDV and 13 coxsackievirus B5 samples, all originally isolated between 1966 and 2006, and analysed these in conjunction with existing sequences and historical information.

Results

While analyses incorporating 24 additional near-complete SVDV genomic sequences indicate clear signs of within-SVDV recombination, all 51 SVDV isol

SUBMITTER: Bruhn CA 

PROVIDER: S-EPMC4661520 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature