Methylation diet and methyl group genetics in risk for adenomatous polyp occurrence.

ABSTRACT:

Purpose

The aim of this study is to explore whether a methylation diet influences risk for adenomatous polyps (AP) either independently, or interactively with one-carbon metabolism-dependent gene variants, and whether such a diet modifies blood homocysteine, a biochemical phenotype closely related to the phenomenon of methylation.

Methods

249 subjects were examined using selective fluorescence, PCR and food frequency questionnaire to determine homocysteine, nine methylation-related gene polymorphisms, dietary methionine, 5-methyltetrahydrofolate, vitamins B6 and B12.

Results

1). Both dietary methionine and 5-methyltetrahydrofolate intake are significantly associated with plasma homocysteine. 2). Dietary methionine is related to AP risk in 2R3R-TS wildtype subjects, wh

SUBMITTER: Lucock M 

PROVIDER: S-EPMC4661521 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature