Lowering blood glucose during hip surgery does not influence coagulation activation.

ABSTRACT:

Background

Hyperglycaemia during and after hip surgery is associated with coagulation activation and an increased risk of venous thromboembolism. Whether lowering of glucose levels during hip surgery diminishes coagulation activation is unknown. We investigated the efficacy of the human GLP-1 analogue liraglutide to lower glucose during and after hip surgery and studied its influence on coagulation activation.

Methods

A total of 37 obese subjects who underwent hip surgery were randomized to subcutaneous liraglutide or placebo for 4 consecutive days, starting one day prior to surgery. Glucose levels and coagulation indices at three fixed time-points (pre-operative, 2 h post-operative and 3 days post-operative) were measured.

Results

Liraglutide reduced glucose at day t

SUBMITTER: Sechterberger MK 

PROVIDER: S-EPMC4661563 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature