Folate status, folate-related genes and serum miR-21 expression: Implications for miR-21 as a biomarker.

ABSTRACT:

Background

Free circulating microRNA (miRNA) in serum may be valuable biomarkers for disease diagnosis and prognosis. miR-21, the archetypal oncogenic miRNA, has been proposed as a biomarker for colorectal cancer and its benign precursor, adenomatous polyps. However, it is now becoming clear that circulating miRNA profiles may be sensitive to lifestyle and environmental influences. Dietary components involved in one-carbon metabolism are particularly well placed to modulate miRNA expression through an influence on DNA methylation pathways.

Methods

We investigated the role of methyl group donors (folate, B12, cysteine, homocysteine), polymorphisms of the enzymes of one-carbon metabolism, and serum miR-21 expression in a primary case-control cohort (colonoscopy confirmed adeno

SUBMITTER: Beckett EL 

PROVIDER: S-EPMC4661713 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature