Preoperative protein profiles in cerebrospinal fluid in elderly hip fracture patients at risk for delirium: A proteomics and validation study.

ABSTRACT:

Background

A neuroinflammatory response is suggested to play an important role in delirium, a common complication in older hospitalized patients. We examined whether hip fracture patients who develop postoperative delirium have a different proteome in cerebrospinal fluid (CSF) prior to surgery.

Methods

Patients (≥ 75 years) were admitted for hip fracture surgery. CSF was collected during spinal anaesthesia; proteins were separated using gel electrophoresis and identified with mass spectrometry. We compared the proteome of patients with and without postoperative delirium. Findings were validated in an independent, comparable cohort using immuno-assays.

Results

In the derivation cohort 53 patients were included, 35.8% developed postoperative delirium. We identified diff

SUBMITTER: Westhoff D 

PROVIDER: S-EPMC4661734 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature