Henrin A: A New Anti-HIV Ent-Kaurane Diterpene from Pteris henryi.

ABSTRACT: Henrin A (1), a new ent-kaurane diterpene, was isolated from the leaves of Pteris henryi. The chemical structure was elucidated by analysis of the spectroscopic data including one-dimensional (1D) and two-dimensional (2D) NMR spectra, and was further confirmed by X-ray crystallographic analysis. The compound was evaluated for its biological activities against a panel of cancer cell lines, dental bacterial biofilm formation, and HIV. It displayed anti-HIV potential with an IC50 value of 9.1 µM (SI = 12.2).

SUBMITTER: Li WF 

PROVIDER: S-EPMC4661929 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature