Multimodular type I polyketide synthases in algae evolve by module duplications and displacement of AT domains in trans.

ABSTRACT:

Background

Polyketide synthase (PKS) catalyzes the biosynthesis of polyketides, which are structurally and functionally diverse natural products in microorganisms and plants. Here, we have analyzed available full genome sequences of microscopic and macroscopic algae for the presence of type I PKS genes.

Results

Type I PKS genes are present in 15 of 32 analyzed algal species. In chlorophytes, large proteins in the MDa range are predicted in most sequenced species, and PKSs with free-standing acyltransferase domains (trans-AT PKSs) predominate. In a phylogenetic tree, PKS sequences from different algal phyla form clades that are distinct from PKSs from other organisms such as non-photosynthetic protists or cyanobacteria. However, intermixing is observed in some cases, for exam

SUBMITTER: Shelest E 

PROVIDER: S-EPMC4661987 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature