Brain-derived Neurotrophic Factor Is Associated with Cognitive Impairment in Elderly Korean Individuals.

ABSTRACT:

Objective

Brain-derived neurotrophic factor (BDNF) is a neurotrophin that is widely expressed in the mammalian brain and acts to regulate neuronal survival and influence cognitive processes. The present study measured serum BDNF levels to investigate the associations of the BDNF Val66Met and 5-hydroxytryptamine transporter linked promoter region (5-HTTLPR) polymorphisms with cognitive function in elderly Korean individuals.

Methods

Over 60 years, a total of 834 subjects were recruited for the present study. The subjects were classified into groups based on the degree of cognitive impairment (age-associated cognitive decline, mild cognitive impairment, and Alzheimer's disease) and compared with normal controls in terms of a neuropsychological assessment and a clinical evaluat

SUBMITTER: Lee SJ 

PROVIDER: S-EPMC4662173 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature