Polo-like kinase 2 acting as a promoter in human tumor cells with an abundance of TAp73.

ABSTRACT:

Background

TAp73, a member of the p53 tumor suppressor family, is frequently overexpressed in malignant tumors in humans. TAp73 abundance and phosphorylation modification result in variations in transcriptional activity. In a previous study, we found that the antitumor function of TAp73 was reactivated by dephosphorylation in head and neck squamous cell carcinomas. Polo-like kinase 2 (PLK2) displayed a close relationship with the p53 family in affecting the fate of cells. Herein, we investigate the hypothesis that PLK2 phosphorylates TAp73 and inhibits TAp73 function.

Materials and methods

Head and neck squamous cell carcinoma cell lines and osteosarcoma cell lines were used as natural models of the different expression levels of TAp73. Phosphorylation predictor software Sca

SUBMITTER: Hu Z 

PROVIDER: S-EPMC4662374 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature