The incidence of Parkinsonism in patients with type 1 Gaucher disease: data from the ICGG Gaucher Registry.

ABSTRACT:

Purpose

Investigate the incidence of Parkinsonism among patients with Gaucher disease type 1 (GD1) and describe demographics, genotypes, and Gaucher disease (GD)-related characteristics for affected and non-affected patients.

Methods

Study type

Cohort study with age- and gender-matched nested case-control analysis. Calculation of event incidence, standardized morbidity ratio, and event-free survival (Kaplan-Meier).

Data source

The International Collaborative Gaucher Group (ICGG) Gaucher Registry data as of June 2010. Study cohort: GD1 patients with any report of Parkinsonism. Pre-matching control group: All GD1 patients with no report of Parkinsonism.

Results

The matched study cohort comprised of 68 patients with reports of Parkinsonism and 649 patients

SUBMITTER: Rosenbloom B 

PROVIDER: S-EPMC4662380 | biostudies-literature | 2011 Jan

REPOSITORIES: biostudies-literature