Targeting Cathepsin B for Cancer Therapies.

ABSTRACT: Cathepsin B is a member of the papain family of cysteine proteases normally present in the lysosome, but it can translocate and function to degrade components of the extracellular matrix. It exhibits carboxyopeptidase, peptidyldipepidase, and endopeptidase activity. Aberrant overexpression of cathepsin B has been reported in invasive and metastatic cancers, including breast cancer, melanoma and colorectal cancer. It has been shown that oncogenic activation, such as the signaling of the ErbB pathways, can lead to cathepsin B overexpression. The degradation of the extracellular matrix is a key factor for cathepsin B to contribute to development and metastasis of tumors. An example of substrates for cathepsin B is E-cadherin, which is involved in adherens junctions, and the downregulation of

SUBMITTER: Ruan H 

PROVIDER: S-EPMC4662557 | biostudies-literature | 2015 2nd Quarter

REPOSITORIES: biostudies-literature