IL-1 Signaling Is Critically Required in Stromal Cells in Kawasaki Disease Vasculitis Mouse Model: Role of Both IL-1α and IL-1β.

ABSTRACT:

Objective

Kawasaki disease (KD) is the most common cause of acute vasculitis and acquired cardiac disease among US children. We have previously shown that both TLR2/MyD88 and interleukin (IL)-1β signaling are required for the Lactobacillus casei cell wall extract-induced KD vasculitis mouse model. The objectives of this study were to investigate the cellular origins of IL-1 production, the role of CD11c(+) dendritic cells and macrophages, and the relative contribution of hematopoietic and stromal cells for IL-1 responsive cells, as well the MyD88 signaling, in Lactobacillus casei cell wall extract-induced KD mouse model of vasculitis.

Approach and results

Using mouse knockout models and antibody depletion, we found that both IL-1α and IL-1β were required for Lactobacillus ca

SUBMITTER: Lee Y 

PROVIDER: S-EPMC4662607 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature