Efficacy of nonvenous medications for acute convulsive seizures: A network meta-analysis.

ABSTRACT:

Objective

This is a network meta-analysis of nonvenous drugs used in randomized controlled trials (RCTs) for treatment of acute convulsive seizures and convulsive status epilepticus.

Methods

Literature was searched according to Preferred Reporting Items for Systematic reviews and Meta-Analyses guidelines for RCTs examining treatment of acute convulsive seizures or status epilepticus with at least one of the study arms being a nonvenous medication. After demographic and outcome data extraction, a Bayesian network meta-analysis was performed and efficacy results were summarized using treatment effects and their credible intervals (CrI). We also calculated the probability of each route-drug combination being the most clinically effective for a given outcome, and provided their

SUBMITTER: Arya R 

PROVIDER: S-EPMC4662705 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature