Custom fit 3D-printed brain holders for comparison of histology with MRI in marmosets.

ABSTRACT:

Background

MRI has the advantage of sampling large areas of tissue and locating areas of interest in 3D space in both living and ex vivo systems, whereas histology has the ability to examine thin slices of ex vivo tissue with high detail and specificity. Although both are valuable tools, it is currently difficult to make high-precision comparisons between MRI and histology due to large differences inherent to the techniques. A method combining the advantages would be an asset to understanding the pathological correlates of MRI.

New method

3D-printed brain holders were used to maintain marmoset brains in the same orientation during acquisition of ex vivo MRI and pathologic cutting of the tissue.

Results

The results of maintaining this same orientation show that sub-mil

SUBMITTER: Guy JR 

PROVIDER: S-EPMC4662872 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature