Intraoperative radiotherapy in colorectal cancer: systematic review and meta-analysis of techniques, long-term outcomes, and complications.

ABSTRACT:

Background

The precise contribution of IORT to the management of locally advanced and recurrent colorectal cancer (CRC) remains uncertain. We performed a systematic review and meta-analysis to assess the value of IORT in this setting.

Methods

Studies published between 1965 and 2011 that reported outcomes after IORT for advanced or recurrent CRC were identified by an electronic literature search. Studies were assessed for methodological quality and design, and evaluated for technique of IORT delivery, oncological outcomes, and complications following IORT. Outcomes were analysed with fixed-effect and random-effect model meta-analyses and heterogeneity and publication bias examined.

Results

29 studies comprising 14 prospective and 15 retrospective studies met the inclus

SUBMITTER: Mirnezami R 

PROVIDER: S-EPMC4663079 | biostudies-literature | 2013 Mar

REPOSITORIES: biostudies-literature