Differentiating zones at periodontal ligament-bone and periodontal ligament-cementum entheses.

ABSTRACT:

Background and objective

The structural and functional integrity of bone-periodontal ligament (PDL)-cementum complex stems from the load-bearing attachment sites (entheses) between soft (PDL) and hard (bone, cementum) tissues. These attachment sites are responsible for the maintenance of a bone-PDL-cementum complex biomechanical function. The objective was to investigate changes in spatiotemporal expression of key biomolecules in developing and functionally active entheses.

Material and methods

Multilabeling technique was performed on hemimandibles of 3 wk and 3 mo-old scleraxis-GFP transgenic mice for CD146, CD31, NG2, osterix and bone sialoprotein. Regions of dominant stretch within the PDL were evaluated by identifying directionality of collagen fibrils, PDL fibroblasts a

SUBMITTER: Lee JH 

PROVIDER: S-EPMC4663098 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature