Finite element models predict the location of microdamage in cancellous bone following uniaxial loading.

ABSTRACT: High-resolution finite element models derived from micro-computed tomography images are often used to study the effects of trabecular microarchitecture and loading mode on tissue stress, but the degree to which existing finite element methods correctly predict the location of tissue failure is not well characterized. In the current study, we determined the relationship between the location of highly strained tissue, as determined from high-resolution finite element models, and the location of tissue microdamage, as determined from three-dimensional fluoroscopy imaging, which was performed after the microdamage was generated in-vitro by mechanical testing. Fourteen specimens of human vertebral cancellous bone were assessed (8 male donors, 2 female donors, 47-78 years of age). Regions of sta

SUBMITTER: Goff MG 

PROVIDER: S-EPMC4663152 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature