UCEPR: Ultrafast localized CEST-spectroscopy with PRESS in phantoms and in vivo.

ABSTRACT:

Purpose

Chemical exchange saturation transfer (CEST) is a contrast mechanism enhancing low-concentration molecules through saturation transfer from their exchangeable protons to bulk water. Often many scans are acquired to form a Z-spectrum, making the CEST method time-consuming. Here, an ultrafast localized CEST-spectroscopy with PRESS (UCEPR) is proposed to obtain the entire Z-spectrum of a voxel using only two scans, significantly accelerating CEST.

Theory and methods

The approach combines ultrafast nonlocalized CEST spectroscopy with localization using PRESS. A field gradient is applied concurrently with the saturation pulse producing simultaneous saturation of all Z-spectrum frequencies that are also spatially encoded. A readout gradient during data acquisition resolves

SUBMITTER: Liu Z 

PROVIDER: S-EPMC4663188 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature