Effect of increased water intake on plasma copeptin in patients with chronic kidney disease: results from a pilot randomised controlled trial.

ABSTRACT:

Objectives

Increased water intake may have a beneficial effect on the kidney through suppression of plasma vasopressin. We examined the effect of increased water intake on plasma copeptin (a marker of vasopressin) over 6 weeks in patients with chronic kidney disease.

Design

Secondary analysis of a randomised controlled parallel-group pilot trial.

Setting

Canada, 2012-2013.

Participants

28 patients with stage 3 chronic kidney disease randomised (2:1) to a hydration (n=17) or control group (n=11).

Intervention

The hydration group was coached to increase water intake by up to 1.5 L/day for 6 weeks. The control group was asked to maintain regular water intake.

Measures and outcomes

Participants provided blood and 24 h urine samples at baseline and 6 w

SUBMITTER: Sontrop JM 

PROVIDER: S-EPMC4663439 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature