Discovery of URAT1 SNPs and association between serum uric acid levels and URAT1.

ABSTRACT:

Objectives

Human urate transporter 1 (URAT1) is a member of the organic anion transporter family (SLC22A12) that primarily regulates the renal tubular reabsorption of uric acid. This case-control study was designed to analyse whether hURAT1 might also be a candidate gene for hyperuricaemia or hypouricaemia.

Setting

We recruited 68 healthy volunteers and divided them into two groups: a normal uric acid group and a hyperuricaemia group. We analysed the sequence of the URAT1 gene and found five significant single nucleotide polymorphisms (SNPs). We then selected 900 male subjects from the 262,200 enrolled in the Korean Cancer Prevention Study-II (KCPS-II) cohort for further genetic analysis.

Participants

DNA samples from 36 individuals with normal uric acid (<4.5 mg/dL)

SUBMITTER: Cho SK 

PROVIDER: S-EPMC4663448 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature